| Edition |
9th ed. |
| Description |
1 online resource (809 pages) |
| Note |
3 user licence. |
| Contents |
Front Cover -- Inside Front Cover -- Rang & Dale's Pharmacology -- Copyright Page -- Table Of Contents -- Rang and Dale's Pharmacology Ninth Edition Preface -- Acknowledgements -- 1 General principles -- 1 What is pharmacology? -- Overview -- What Is a Drug? -- Origins and Antecedents -- Pharmacology in the 20Th and 21St Centuries -- Alternative Therapeutic Principles -- The Emergence of Biotechnology -- Pharmacology Today -- Pharmacogenomics. -- Pharmacoepidemiology. -- Pharmacoeconomics. -- References and Further Reading -- 2 How drugs act -- Overview -- Introduction -- Protein Targets for Drug Binding -- Drug Receptors -- What Do We Mean by Receptors? -- Receptors in Physiological Systems -- Drug Specificity -- Receptor Classification -- Drug-Receptor Interactions -- The Binding of Drugs to Receptors -- The Relation Between Drug Concentration and Effect -- Spare Receptors -- Competitive Antagonism -- Irreversible Competitive Antagonism -- Partial Agonists and the Concept of Efficacy -- Partial Agonists as Antagonists -- Constitutive Receptor Activation and Inverse Agonists -- The two-state receptor model -- Biased Agonism -- Allosteric Modulation -- Other Forms of Drug Antagonism -- Chemical Antagonism -- Pharmacokinetic Antagonism -- Block of Receptor-Response Linkage -- Physiological Antagonism -- Desensitisation and Tolerance -- Change in Receptors -- Translocation of Receptors -- Exhaustion of Mediators -- Altered Drug Metabolism -- Physiological Adaptation -- Quantitative Aspects of Drug-Receptor Interactions -- The Binding Reaction -- Binding When More Than One Drug Is Present -- The Nature of Drug Effects -- References and Further Reading -- General -- Receptor mechanisms: agonists and efficacy -- 3 How drugs act -- Overview -- Protein Targets for Drug Action -- Receptors -- Ion Channels -- Enzymes -- Transporters -- Receptor Proteins. |
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Cloning of Receptors -- Types of Receptor -- Molecular Structure of Receptors -- Receptor Heterogeneity and Subtypes -- Type 1: Ligand-Gated Ion Channels -- Molecular Structure -- The Gating Mechanism -- Type 2: G Protein-Coupled Receptors -- Molecular Structure -- Proteinase-Activated Receptors -- G Proteins and Their Role -- Targets for G Proteins -- The adenylyl cyclase/cAMP system -- The phospholipase C/inositol phosphate system -- Inositol phosphates and intracellular calcium -- Diacylglycerol and protein kinase C -- Ion channels as targets for G proteins -- The Rho/Rho kinase system -- The MAP kinase system -- Further Developments in GPCR Biology -- GPCR desensitisation -- GPCR oligomerisation -- Constitutively active receptors -- Agonist specificity -- Receptor activity-modifying proteins -- G protein-independent signalling -- Type 3: Kinase-Linked and Related Receptors -- Receptor tyrosine kinases (RTKs). -- Receptor serine/threonine kinases. -- Cytokine receptors. -- Protein Phosphorylation and Kinase Cascade Mechanisms -- Type 4: Nuclear Receptors -- Structure of Nuclear Receptors -- Control of Gene Transcription -- Classification of Nuclear Receptors -- Ion Channels as Drug Targets -- Ion Selectivity -- Gating -- Voltage-Gated Channels -- Ligand-Gated Channels -- Calcium Release Channels -- Store-Operated Calcium Channels -- Molecular Architecture of Ion Channels -- Pharmacology of Ion Channels -- Control of Receptor Expression -- Receptors and Disease -- References and Further Reading -- General -- Ion channels -- G protein-coupled receptors -- Signal transduction -- Kinase-linked receptors -- Nuclear receptors -- 4 How drugs act -- Overview -- Regulation of Intracellular Calcium -- Calcium Entry Mechanisms -- Voltage-Gated Calcium Channels -- Ligand-Gated Channels -- Store-Operated Calcium Channels (SOCs) -- Calcium Extrusion Mechanisms. |
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Calcium Release Mechanisms -- Other Second Messengers -- The Role of Mitochondria -- Calmodulin -- Excitation -- The 'Resting' Cell -- Electrical and Ionic Events Underlying the Action Potential -- Channel Function -- Use Dependence and Voltage Dependence -- Sodium Channels -- Potassium Channels -- Muscle Contraction -- Skeletal Muscle -- Cardiac Muscle -- Smooth Muscle -- Release of Chemical Mediators -- Exocytosis -- Non-Vesicular Release Mechanisms -- Epithelial Ion Transport -- References and Further Reading -- General references -- Excitation and ion channels -- Muscle contraction -- Secretion and exocytosis -- 5 How drugs act -- Overview -- Introduction -- Protein and Oligonucleotide Biopharmaceuticals -- Proteins and Polypeptides -- Production methods -- Engineered proteins -- Monoclonal Antibodies -- Oligonucleotides -- Pharmacology of Protein and Oligonucleotide Pharmaceuticals -- Gene Therapy -- Gene Delivery -- Viral Vectors -- Retroviruses -- Adenovirus -- Other viral vectors -- Non-Viral Vectors -- Liposomes -- Microspheres -- Plasmid DNA -- Controlling Gene Expression -- Safety and Societal Issues -- Therapeutic Applications -- Concluding Remarks -- References and Further Reading -- General reviews on biopharmaceuticals, gene therapy and utilities -- Problems -- Therapeutic uses -- 6 Cell proliferation, apoptosis, repair and regeneration -- Overview -- Cell Proliferation -- The Cell Cycle -- Positive Regulators of the Cell Cycle -- Negative Regulators of the Cell Cycle -- Inhibition of the cycle at check point 1 -- Inhibition of the cycle at check point 2 -- Interactions Between Cells, Growth Factors and the Extracellular Matrix -- The Role of Integrins -- The Role of Matrix Metalloproteinases -- Angiogenesis -- Apoptosis and Cell Removal -- Morphological Changes in Apoptosis -- The Major Players in Apoptosis -- Pathways to Apoptosis. |
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The Extrinsic Pathway -- The mitochondrial pathway -- MicroRNAs, the cell cycle and apoptosis -- Pathophysiological Implications -- Repair and Healing -- Hyperplasia -- The Growth, Invasion and Metastasis of Tumours -- Stem Cells and Regeneration -- Therapeutic Prospects -- Apoptotic Mechanisms -- Angiogenesis and Metalloproteinases -- Cell Cycle Regulation -- References and Further Reading -- Cell cycle and apoptosis (general) -- Integrins, extracellular matrix, metalloproteinases and angiogenesis -- Stem cells, regeneration and repair -- 7 Cellular mechanisms -- Overview -- Introduction -- The Innate Immune Response -- Pattern Recognition -- Responses to Pattern Recognition -- Vascular events -- Cellular events -- Polymorphonuclear leukocytes -- Mast cells -- Monocytes/macrophages -- Dendritic cells -- Eosinophils -- Basophils -- Vascular endothelial cells -- Platelets -- Natural killer cells -- The Adaptive Immune Response -- The Induction Phase -- The Effector Phase -- The Antibody-Mediated (Humoral) Response -- Antibodies and complement -- Antibodies and the phagocytosis of bacteria -- Antibodies and cellular toxicity -- Antibodies and mast cells or basophils -- The Cell-Mediated Immune Response -- Cytotoxic T cells -- Macrophage activating CD4+ Th1 cells -- Systemic Responses in Inflammation -- The Role of the Nervous System in Inflammation -- Unwanted Inflammatory and Immune Responses -- Type I hypersensitivity -- Type II hypersensitivity -- Type III hypersensitivity -- Type IV hypersensitivity -- The Outcome of the Inflammatory Response -- References and Further Reading -- The innate and adaptive responses -- Books -- 8 Method and measurement in pharmacology -- Overview -- Bioassay -- Biological Test Systems -- General Principles of Bioassay -- The Use of Standards -- The Design of Bioassays -- Animal Models of Disease. |
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Genetic and Transgenic Animal Models -- Pharmacological Studies in Humans -- Clinical Trials -- Avoidance of Bias -- The Size of the Sample -- Clinical Outcome Measures -- Placebos -- Meta-Analysis -- Balancing Benefit and Risk -- Therapeutic Index -- Other Measures of Benefit and Risk -- References and Further Reading -- General references -- Molecular methods -- Animal models -- Clinical trials -- 9 Absorption and distribution of drugs -- Overview -- Introduction -- Physical Processes Underlying Drug Disposition -- The Movement of Drug Molecules Across Cell Barriers -- Diffusion Through Lipid -- Ion Trapping -- pH and ionisation -- pH partition and ion trapping -- Carrier-Mediated Transport -- Organic cation transporters and organic anion transporters -- P-glycoprotein transporters -- Plasma protein and tissue partition of drugs -- Binding of Drugs to Plasma Proteins -- Partition Into Body Fat and Other Tissues -- Drug Absorption and Routes of Administration -- Oral Administration -- Drug Absorption From the Intestine -- Factors Affecting Gastrointestinal Absorption -- Bioavailability and bioequivalence -- Oromucosal (Sublingual or Buccal) Administration -- Rectal Administration -- Application to Epithelial Surfaces -- Cutaneous Administration -- Nasal Sprays -- Eye Drops -- Administration by Inhalation -- Administration by Injection -- Methods for Delaying Absorption -- Intrathecal Injection -- Intravitreal Injection -- Distribution of Drugs in the Body -- Body Fluid Compartments -- The Blood-Brain Barrier -- Volume of Distribution -- Drugs Largely Confined to the Plasma Compartment -- Drugs Distributed in the Extracellular Compartment -- Distribution Throughout the Body Water -- Drug Interactions Caused by Altered Absorption (See Ch. 12 for a General Approach to Drug Interactions). |
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Drug Interactions Caused by Altered Distribution (See Ch. 12 for a General Approach to Drug Interactions). |
| Note |
Description based on publisher supplied metadata and other sources. |
| Local Note |
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. |
| Genre/Form |
Electronic books. |
| Added Author |
Flower, Rod J.
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Henderson, Graeme.
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Loke, Yoon Kong.
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MacEwan, David.
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Rang, Humphrey P.
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| Other Form: |
Print version: Ritter, James M. Rang and Dale's Pharmacology E-Book Philadelphia : Elsevier,c2018 9780702074486 |
| ISBN |
9780702074462 (electronic bk.) |
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